腺苷脱氨酶

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腺苷脱氨酶

牛腺苷脱氨酶的丝带图。可见中央的锌离子。来自PDB 1VFL

有效结构

PDB

直系同源检索：PDBe, RCSB

PDB查询代码列表
1M7M, 3IAR

标识

代号

ADA;

扩展标识

遗传学：608958 鼠基因：87916 同源基因：37249 GeneCards: ADA Gene

EC编号

3.5.4.4

基因本体论描述
分子功能	· purine nucleoside binding · adenosine deaminase activity · adenosine deaminase activity · adenosine deaminase activity · protein binding · zinc ion binding · zinc ion binding · hydrolase activity · metal ion binding
细胞成分	· extracellular space · cytoplasm · lysosome · cytosol · plasma membrane · external side of plasma membrane · cell surface · membrane · cell junction · cytoplasmic vesicle · dendrite cytoplasm · neuronal cell body · cytoplasmic membrane-bounded vesicle lumen
生物过程	· response to hypoxia · in utero embryonic development · trophectodermal cell differentiation · liver development · placenta development · germinal center B cell differentiation · positive regulation of germinal center formation · negative regulation of leukocyte migration · negative regulation of mature B cell apoptosis · purine base metabolic process · adenosine catabolic process · adenosine catabolic process · deoxyadenosine catabolic process · cell adhesion · aging · nucleotide metabolic process · purine ribonucleoside monophosphate biosynthetic process · positive regulation of heart rate · positive regulation of B cell proliferation · purine nucleotide salvage · positive regulation of T cell differentiation in thymus · regulation of cell-cell adhesion mediated by integrin · T cell activation · response to hydrogen peroxide · negative regulation of apoptosis · purine-containing compound salvage · regulation of circadian sleep/wake cycle, sleep · positive regulation of smooth muscle contraction · dATP catabolic process · hypoxanthine biosynthetic process · inosine biosynthetic process · inosine biosynthetic process · xanthine biosynthetic process · positive regulation of alpha-beta T cell differentiation · lung alveolus development · Peyer's patch development · embryonic digestive tract development · negative regulation of inflammatory response · positive regulation of calcium-mediated signaling · positive regulation of T cell receptor signaling pathway · nucleobase, nucleoside and nucleotide metabolic process · negative regulation of adenosine receptor signaling pathway · negative regulation of penile erection · negative regulation of thymocyte apoptosis · negative regulation of mucus secretion
Sources: Amigo / QuickGO

RNA表达模式

更多表达数据

直系同源体

物种

人类

鼠类

Entrez

Ensembl

UniProt

mRNA序列

蛋白序列

基因位置

Chr 20:
43.25 – 43.28 Mb

Chr 2:
163.55 – 163.58 Mb

PubMed查询

[1]

[2]

Adenosine/AMP deaminase

crystal structure of plasmodium yoelii adenosine deaminase (py02076)

鉴定

标志

A_deaminase

Pfam（蛋白家族查询站）

Pfam宗系

InterPro（蛋白数据整合站）

PROSITE（蛋白数据站）

SCOP（蛋白结构分类数据站）

现有可用的蛋白结构：
Pfam	structures
PDB（蛋白质数据库）	RCSB PDB; PDBe
PDBsum（蛋白质三维结构站）	structure summary

Adenosine deaminase (editase) domain

鉴定

标志

A_deamin

Pfam（蛋白家族查询站）

InterPro（蛋白数据整合站）

PROSITE（蛋白数据站）

SCOP（蛋白结构分类数据站）

现有可用的蛋白结构：
Pfam	structures
PDB（蛋白质数据库）	RCSB PDB; PDBe
PDBsum（蛋白质三维结构站）	structure summary

Adenosine/AMP deaminase N-terminal

鉴定

标志

A_deaminase_N

Pfam（蛋白家族查询站）

PF08451

InterPro（蛋白数据整合站）

IPR013659

现有可用的蛋白结构：
Pfam	structures
PDB（蛋白质数据库）	RCSB PDB; PDBe
PDBsum（蛋白质三维结构站）	structure summary

腺苷脱氨酶（英语：Adenosine deaminase）的是一种参与嘌呤代谢作用的酶。它是用作拆解食物组织中的核酸中的腺苷。

反应

腺苷脱氨酶对腺苷进行不可逆转的脱氨作用,转化腺苷为相关的核苷肌苷,移除氨基酸组。

病理学

腺苷脱氨酶的突变基因使之不容易被表达,这是一些免疫缺陷病（ SCID ）的原因。基因突变令ADA被过度产生是溶血性贫血原因之一。有一些证据表明，一个不同的allelle (ADA2)可能会导致自闭症。

参考文献

深入阅读

da Cunha JG. [Adenosine deaminase. A pluridisciplinary enzyme]. Acta médica portuguesa. 1992, 4 (6): 315–23. PMID 1807098.
Franco R, Casadó V, Ciruela F, et al.. Cell surface adenosine deaminase: much more than an ectoenzyme. Prog. Neurobiol.. 1997, 52 (4): 283–94. doi:10.1016/S0301-0082(97)00013-0. PMID 9247966.
Valenzuela A, Blanco J, Callebaut C, et al.. HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26. Adv. Exp. Med. Biol.. 1997, 421: 185–92. PMID 9330696.
Moriwaki Y, Yamamoto T, Higashino K. Enzymes involved in purine metabolism--a review of histochemical localization and functional implications. Histol. Histopathol.. 1999, 14 (4): 1321–40. PMID 10506947.
Hirschhorn R. Identification of two new missense mutations (R156C and S291L) in two ADA- SCID patients unusual for response to therapy with partial exchange transfusions. Hum. Mutat.. 1993, 1 (2): 166–8. doi:10.1002/humu.1380010214. PMID 1284479.
Berkvens TM, van Ormondt H, Gerritsen EJ, et al.. Identical 3250-bp deletion between two AluI repeats in the ADA genes of unrelated ADA-SCID patients. Genomics. 1990, 7 (4): 486–90. doi:10.1016/0888-7543(90)90190-6. PMID 1696926.
Aran JM, Colomer D, Matutes E, et al.. Presence of adenosine deaminase on the surface of mononuclear blood cells: immunochemical localization using light and electron microscopy. J. Histochem. Cytochem.. 1991, 39 (8): 1001–8. PMID 1856451.
Bielat K, Tritsch GL. Ecto-enzyme activity of human erythrocyte adenosine deaminase. Mol. Cell. Biochem.. 1989, 86 (2): 135–42. doi:10.1007/BF00222613. PMID 2770711.
Hirschhorn R, Tzall S, Ellenbogen A, Orkin SH. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC303706/ Identification of a point mutation resulting in a heat-labile adenosine deaminase (ADA) in two unrelated children with partial ADA deficiency]. J. Clin. Invest.. 1989, 83 (2): 497–501. doi:10.1172/JCI113909. PMID 2783588. PMC 303706.
Murray JL, Perez-Soler R, Bywaters D, Hersh EM. Decreased adenosine deaminase (ADA) and 5'nucleotidase (5NT) activity in peripheral blood T cells in Hodgkin disease. Am. J. Hematol.. 1986, 21 (1): 57–66. doi:10.1002/ajh.2830210108. PMID 3010705.
Wiginton DA, Kaplan DJ, States JC, et al.. Complete sequence and structure of the gene for human adenosine deaminase. Biochemistry. 1987, 25 (25): 8234–44. doi:10.1021/bi00373a017. PMID 3028473.
Akeson AL, Wiginton DA, Dusing MR, et al.. Mutant human adenosine deaminase alleles and their expression by transfection into fibroblasts. J. Biol. Chem.. 1988, 263 (31): 16291–6. PMID 3182793.
Glader BE, Backer K. Elevated red cell adenosine deaminase activity: a marker of disordered erythropoiesis in Diamond-Blackfan anaemia and other haematologic diseases. Br. J. Haematol.. 1988, 68 (2): 165–8. doi:10.1111/j.1365-2141.1988.tb06184.x. PMID 3348976.
Petersen MB, Tranebjaerg L, Tommerup N, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1049896/ New assignment of the adenosine deaminase gene locus to chromosome 20q13 X 11 by study of a patient with interstitial deletion 20q]. J. Med. Genet.. 1987, 24 (2): 93–6. doi:10.1136/jmg.24.2.93. PMID 3560174. PMC 1049896.
Orkin SH, Goff SC, Kelley WN, Daddona PE. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC366780/ Transient expression of human adenosine deaminase cDNAs: identification of a nonfunctional clone resulting from a single amino acid substitution]. Mol. Cell. Biol.. 1985, 5 (4): 762–7. PMID 3838797. PMC 366780.
Valerio D, Duyvesteyn MG, Dekker BM, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC554205/ Adenosine deaminase: characterization and expression of a gene with a remarkable promoter]. EMBO J.. 1985, 4 (2): 437–43. PMID 3839456. PMC 554205.
Bonthron DT, Markham AF, Ginsburg D, Orkin SH. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC423929/ Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency]. J. Clin. Invest.. 1985, 76 (2): 894–7. doi:10.1172/JCI112050. PMID 3839802. PMC 423929.
Daddona PE, Shewach DS, Kelley WN, et al.. Human adenosine deaminase. cDNA and complete primary amino acid sequence. J. Biol. Chem.. 1984, 259 (19): 12101–6. PMID 6090454.
Valerio D, Duyvesteyn MG, Meera Khan P, et al.. Isolation of cDNA clones for human adenosine deaminase. Gene. 1984, 25 (2-3): 231–40. doi:10.1016/0378-1119(83)90227-5. PMID 6198240.

蛋白质数据库图集

1krm: Crystal structure of bovine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine riboside

1ndv: Crystal Structure of Adenosine Deaminase complexed with FR117016

1ndw: Crystal Structure of Adenosine Deaminase Complexed with FR221647

1ndy: Crystal Structure of Adenosine Deaminase Complexed with FR230513

1ndz: Crystal Structure of Adenosine Deaminase Complexed with FR235999

1o5r: Crystal structure of adenosine deaminase complexed with a potent inhibitor

1qxl: Crystal structure of Adenosine deaminase complexed with FR235380

1uml: Crystal structure of adenosine deaminase complexed with a potent inhibitor FR233624

1v79: Crystal structures of adenosine deaminase complexed with potent inhibitors

1v7a: Crystal structures of adenosine deaminase complexed with potent inhibitors

1vfl: Adenosine deaminase

1w1i: CRYSTAL STRUCTURE OF DIPEPTIDYL PEPTIDASE IV (DPPIV OR CD26) IN COMPLEX WITH ADENOSINE DEAMINASE

1wxy: Crystal structure of adenosine deaminase ligated with a potent inhibitor

1wxz: Crystal structure of adenosine deaminase ligated with a potent inhibitor

2bgn: HIV-1 TAT PROTEIN DERIVED N-TERMINAL NONAPEPTIDE TRP2-TAT (1-9) BOUND TO THE ACTIVE SITE OF DIPEPTIDYL PEPTIDASE IV (CD26)

2e1w: Crystal structure of adenosine deaminase complexed with potent inhibitors

水解酶类：碳-氮非肽（EC 3.5）

3.5.1：线性酰胺/ 酰胺水解酶	天冬酰胺酶 · 谷氨酰胺酶 · 脲酶 · 生物素酶 · 天冬氨酸酰酶 · 神经酰胺酶 · 天门冬酰胺氨基葡萄糖酶 · 脂肪酰胺水解酶 · 组蛋白脱乙酰酶（乙酰化酶）

3.5.2：环状酰胺/ 酰胺水解酶	丙二酰脲酶 · β-内酰胺酶

3.5.3：线性脒/ 脲水解酶	精氨酸酶 · 鲱精胺酶 · 蛋白质-精氨酸脱亚氨酶

3.5.4：环状脒/ 氨基水解酶	鸟嘌呤脱氨酶 · 腺苷脱氨酶 · AMP脱氨酶 · 肌苷单磷酸合酶 · DCMP脱氨酶 · GTP环水解酶I · 胞苷脱氨酶（AICDA、活化诱导的（胞苷）脱氨酶）

3.5.5：腈/ 氨基水解酶	腈水解酶

3.5.99：其他	核黄素酶 · 硫胺酶II

EC 1.1/2/3/4/5/6/7/8/9/10/11/12/13/14/15/16/17/18/19/20/21/22 · 2.1/2/3/4/5/6/7(2.7.10/11-12)/8/9 · 3.1/2/3/4(3.4.21/22/23/24)/5/6/7/8/9/10/11/12/13 · 4.1/2/3/4/5/6 · 5.1/2/3/4/5 · 6.1/2/3/4/5/6

代谢：核苷酸代谢 · 核苷酸酶

嘌呤代谢

合成代谢	R5P->IMP：核糖-磷酸二磷酸激酶 · 酰胺基磷酸核糖基转移酶 · 磷酸核糖基甘氨酰胺甲酰基转移酶 · AIR synthetase (FGAM cyclase) · 磷酸核糖酰氨基咪唑羧化酶 · 磷酸核糖酰氨咪唑琥珀酸甲酰胺合酶 · IMP合酶 IMP->AMP：腺嘌呤琥珀酸合酶 · 腺苷酸琥珀酸裂解酶 · reverse (AMP deaminase) IMP->GMP： IMP脱氢酶 · GMP合酶 · reverse (GMP reductase)

核苷酸补救	次黄嘌呤-鸟嘌呤磷酸核糖基转移酶 · 腺嘌呤磷酸核糖转移酶

分解代谢	腺苷脱氨酶 · 嘌呤核苷磷酸化酶 · 鸟嘌呤脱氨酶 · 黄嘌呤氧化酶 · 尿酸氧化酶

嘧啶代谢

合成代谢	CAD (氨甲酰磷酸合酶II、天冬氨酸转氨甲酰酶、二氢乳清酸酶) 双氢乳清酸酯脱氢酶 · 乳清酸核苷5'-磷酸脱羧酶/尿苷酸合成酶 CTP synthase

分解代谢	二氢嘧啶脱氢酶 · 二氢嘧啶酶/DPYS · β-脲基丙酸酶/UPB1

脱氧核苷酸

核糖核苷酸还原酶 · 核苷-二磷酸激酶 · DCMP脱氨酶 · 胸苷酸合酶 · 二氢叶酸还原酶

参考来源

维基百科-腺苷脫氨酶

5个分类: 人类蛋白质 | 需要图片的蛋白质页面 | 酶 | EC 3.5.4 | 免疫兴奋药

腺苷脱氨酶

目录

反应

病理学

参考文献

深入阅读

参考来源